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In his fourth incarnation, the Doctor landed on the planet Zeta Minor, a world located on the edge of the known universe, the bridge-point for the opposite universes of matter and anti-matter.Now in his fifth life, the Doctor meets the same race the landed there before, and once again they are eager to harness its secrets -- with terrifyingly dangerous results.Caught up in a situation akin to a Jacobean revenge tragedy, the Doctor must fight his way through layers of court intrigue before he can try to stop the people really in control from allowing the forces of Anti-matter free reign to destroy every life-form in the universe.

Millenia ago, the Vanir ripped a hole in reality and created a gateway to the Higher Dimensions. This resulted in the warping of vast areas of space, and anyone who perceived these Higher Dimensions went insane. The Vanier disappeared into the gateway and all that remains of them is shimmering, golden palace floating in the clouds... The Doctor inadvertently materializes on Ashkellia, where Valdemar's tomb lies. The Doctor must escape imprisonment by Neville, a debauched aristocrat, to save both the universe and himself from the Higher Dimensions.

Thirty years ago, the Earth was covertly attacked by the alien Myloki, who brainwashed humans and seeded them into Earth society as terrorists and assassins. Earth governments pooled their resources and financed Operation PRISM to fight - and win - the secret war against the Myloki. Now the successor to PRISM, the SILHOUETTE organization, runs a series of Early Warning devices in space, should the dreaded Myloki return. But the financial burden of the war has caused global financial meltdown and Earth stands on the brink of anarchy.

The Second Doctor, Jamie and Zoe discover the war was in fact faked by a corrupt Earth dictatorship that has turned the planet into a tightly controlled utopia. Drugs keep the population under strict and docile control. Humanity is reduced to little more than work units. With the help of war hero Captain Grant Matthews, a PRISM agent accidentally made indestructible during the war, the Doctor, Jamie, and Zoe gradually discover the truth - but in doing so they face the opposition of a whole planet.